S3I-201 (NSC 74859)
S3I-201
CAS: 501919-59-1
Molecular Formula: C16H15NO7S
S3I-201 (NSC 74859) - Names and Identifiers
S3I-201 (NSC 74859) - Physico-chemical Properties
| Molecular Formula | C16H15NO7S |
| Molar Mass | 365.36 |
| Density | 1.507 |
| Melting Point | >185oC (dec.) |
| Boling Point | 654.7±55.0 °C(Predicted) |
| Solubility | DMSO: >10mg/mL |
| Appearance | powder |
| Color | white to beige |
| pKa | 2.98±0.10(Predicted) |
| Storage Condition | -20°C |
| MDL | MFCD09907564 |
| Use | S3I-201 |
| In vitro study | S3I-201 selectively inhibits Stat3 DNA binding activity. S3I-201 inhibits the complex form of Stat3 · Stat3, independent of the activation state of STAT3. S3I-201 does not interfere with the binding of Lck SH2 to the homologous pTyr peptide. S3I-201 action on NIH 3T3/v-Src murine fibroblasts and human breast cancer MDA-MB-231, MDA-MB-435, and MDA-MB-468 cells inhibits Stat3 activation. S3I-201 inhibits stat3-dependent transcriptional activity. S3I-201 also inhibited the expression of stat3-regulated genes encoding cyclin D1, Bcl-xL, and survival. S3I-201 can reduce pS727STAT3 levels and reduce TGF-beta pathway protein levels. S3I-201 also inhibited CD133 and CD133 − Huh-7 cells. The latest study shows that S3I-201 acts on Hep-G2, Huh-7 and SK-HEP-1 cells, potentiating the antiproliferative effects of Cetuximab. |
| In vivo study | 5 mg/kg dose of S3I-201 in mice carrying human breast cancer (MDA-MB-231), showed a strong inhibitory effect. S3I-201 at a dose of 5 mg/kg showed strong anticancer activity in the Huh-7 xenograft tumor, with no significant external health changes or weight loss symptoms. |
S3I-201 (NSC 74859) - Risk and Safety
| WGK Germany | 3 |
S3I-201 (NSC 74859) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.737 ml | 13.685 ml | 27.37 ml |
| 5 mM | 0.547 ml | 2.737 ml | 5.474 ml |
| 10 mM | 0.274 ml | 1.369 ml | 2.737 ml |
| 5 mM | 0.055 ml | 0.274 ml | 0.547 ml |
Last Update：2024-01-02 23:10:35
S3I-201 (NSC 74859) - Reference Information
| biological activity | S3I-201 effectively inhibited fstat3 DNA binding activity, IC50 was 86 μm, and the inhibition of STAT1 and STAT5 was weak. S3I-201 (NSC 74859) effectively inhibited the DNA binding activity of STAT3 with an IC50 of 86 μm, while the inhibitory activity against STAT1 and STAT5 was low. |
| features | S3I-201 is a chemical detector inhibitor that removes breast tumors. |
| Target | Value |
| STAT3 (Cell-free assay) | 86 μM |
Last Update：2024-04-10 22:29:15
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Featured ProductsSpot supply
Product Name: S3I-201 Visit Supplier Webpage Request for quotationCAS: 501919-59-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: S3I-201 Visit Supplier Webpage Request for quotationCAS: 501919-59-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: S3I-201 Visit Supplier Webpage Request for quotationCAS: 501919-59-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: S3I-201 Visit Supplier Webpage Request for quotationCAS: 501919-59-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
S3I-201 (NSC 74859)
3-{[((叔丁氧基)羰基](丙-2-基)氨基}丙酸
MCH-GENE-OVERPRINTED-POLYPEPTIDE-14 (RAT)
阿夫唑嗪(N-[3-[(4-氨基-6,7-二甲氧基-2-喹唑啉基)甲基氨基丙基]四氢-2-呋喃甲酰胺)
PEG-4 POLYGLYCERYL-2 DISTEARATE
Methyl 4-bromophenylaceta...
3-{[((叔丁氧基)羰基](丙-2-基)氨基}丙酸
MCH-GENE-OVERPRINTED-POLYPEPTIDE-14 (RAT)
阿夫唑嗪(N-[3-[(4-氨基-6,7-二甲氧基-2-喹唑啉基)甲基氨基丙基]四氢-2-呋喃甲酰胺)
PEG-4 POLYGLYCERYL-2 DISTEARATE
Methyl 4-bromophenylaceta...